Copper homeostasis and cuproptosis in health and disease

L Chen, J Min, F Wang - Signal transduction and targeted therapy, 2022 - nature.com
As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Ironing out the role of ferroptosis in immunity

HN Bell, BR Stockwell, W Zou - Immunity, 2024 - cell.com
Ferroptosis is a type of regulated cell death that drives the pathophysiology of many
diseases. Oxidative stress is detectable in many types of regulated cell death, but only …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - Signal transduction and …, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

[HTML][HTML] Ferroptosis in health and disease

C Berndt, H Alborzinia, VS Amen, S Ayton, U Barayeu… - Redox biology, 2024 - Elsevier
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …

Iron imbalance in neurodegeneration

S Levi, M Ripamonti, AS Moro, A Cozzi - Molecular psychiatry, 2024 - nature.com
Iron is an essential element for the development and functionality of the brain, and
anomalies in its distribution and concentration in brain tissue have been found to be …

The neuropathobiology of multiple sclerosis

MS Woo, JB Engler, MA Friese - Nature Reviews Neuroscience, 2024 - nature.com
Chronic low-grade inflammation and neuronal deregulation are two components of a
smoldering disease activity that drives the progression of disability in people with multiple …

Ferroptosis: principles and significance in health and disease

F Chen, R Kang, D Tang, J Liu - Journal of hematology & oncology, 2024 - Springer
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …

The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

E Van San, AC Debruyne, G Veeckmans… - Cell Death & …, 2023 - nature.com
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous
(CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is …

[HTML][HTML] Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases

Y Wang, M Lv, W Zhao - Ageing research reviews, 2023 - Elsevier
Ferroptosis is an iron-and lipid peroxidation (LPO)-mediated programmed cell death type.
Recently, mounting evidence has indicated the involvement of ferroptosis in …