The three-dimensional organization of the genome plays a central role in the regulation of
cellular functions, particularly in the human brain. This review explores the intricacies of …

Enhancers are non‐coding DNA elements that play a crucial role in enhancing the
transcription rate of a specific gene in the genome. Experiments for identifying enhancers …

Enhancers are deoxyribonucleic acid (DNA) fragments which when bound by transcription
factors enhance the transcription of related genes. Due to its sporadic distribution and …

Background: Cardiac chamber-selective transcriptional programs underpin the structural
and functional differences between atrial and ventricular cardiomyocytes (aCMs and vCMs) …

Precise control of gene expression during differentiation relies on the interplay of chromatin
and nuclear structure. Despite an established contribution of nuclear membrane proteins to …

Background Super-enhancers are clusters of enhancer elements that play critical roles in
the maintenance of cell identity. Current investigations on super-enhancers are centered on …

Background Regulation of transcription is central to the emergence of new cell types during
development, and it often involves activation of genes via proximal and distal regulatory …

At high altitude Andean region, hypoxia-induced excessive erythrocytosis (EE) is the
defining feature of Monge's disease or chronic mountain sickness (CMS). At the same …

Multi-UTR genes are widely transcribed and express their alternative 3′ UTR isoforms in a
cell type-specific manner. As transcriptional enhancers regulate mRNA expression, we …

Age‐related skeletal muscle atrophy or sarcopenia is a significant societal problem that is
becoming amplified as the world's population continues to increase. The regeneration of …