There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

Microglia are brain macrophages that mediate neuroinflammation and contribute to and
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …

Introduction Intravitreal anti-vascular endothelial growth factor (VEGF) injections for
exudative age-related macular degeneration (eAMD) are effective and safe but require …

Aging, in a large measure, has long been defined as the resultant of oxidative stress acting
on the cells. The cellular machinery eventually malfunctions at the basic level by the …

Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are
mostly found as terminal residues in glycan structures of glycoconjugates including both …

Activation of the nuclear factor erythroid 2–related factor 2 (Nrf2) pathway is critical for
vascular endothelial redox homeostasis in regions of high, unidirectional shear stress …

Sialic acids are monosaccharides that normally terminate the glycan chains of cell surface
glyco‐proteins and‐lipids in mammals, and are highly enriched in the central nervous tissue …

Neurons communicate with each other through electrochemical transmission at synapses.
Microglia, the resident immune cells of the central nervous system, modulate this …

Microglia are resident myeloid cells in the central nervous system (CNS) with a unique
developmental origin, playing essential roles in develo** and maintaining the CNS …