Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …
progression leads to joint deformity and associated loss of function, which significantly …
Role of Bruton's tyrosine kinase in B cells and malignancies
Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …
signaling that is critical for proliferation and survival of leukemic cells in many B cell …
ANCA-associated vasculitis: an update
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) represents a group
of small vessel vasculitides characterized by granulomatous and neutrophilic tissue …
of small vessel vasculitides characterized by granulomatous and neutrophilic tissue …
Pemphigus: current and future therapeutic strategies
D Didona, R Maglie, R Eming, M Hertl - Frontiers in immunology, 2019 - frontiersin.org
Pemphigus encompasses a heterogeneous group of autoimmune blistering diseases, which
affect both mucous membranes and the skin. The disease usually runs a chronic-relapsing …
affect both mucous membranes and the skin. The disease usually runs a chronic-relapsing …
LAG-3 inhibitory receptor expression identifies immunosuppressive natural regulatory plasma cells
B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious,
autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset …
autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset …
Фармакотерапия ревматоидного артрита: новая стратегия, новые мишени
ЕЛ Насонов - Научно-практическая ревматология, 2017 - cyberleninka.ru
Ревматоидный артрит (РА) хроническое иммуновоспалительное (аутоиммунное)
заболевание, проявляющееся прогрессирующей деструкцией суставов, системным …
заболевание, проявляющееся прогрессирующей деструкцией суставов, системным …
Efficacy, safety, and pharmacodynamic effects of the Bruton's tyrosine kinase inhibitor fenebrutinib (GDC‐0853) in systemic lupus erythematosus: results of a phase II …
D Isenberg, R Furie, NS Jones, P Guibord… - Arthritis & …, 2021 - Wiley Online Library
Objective Fenebrutinib (GDC‐0853) is a noncovalent, oral, and highly selective inhibitor of
Bruton's tyrosine kinase (BTK). The efficacy, safety, and pharmacodynamics of fenebrutinib …
Bruton's tyrosine kinase (BTK). The efficacy, safety, and pharmacodynamics of fenebrutinib …
The role of Bruton's tyrosine kinase in the immune system and disease
C McDonald, C Xanthopoulos, E Kostareli - Immunology, 2021 - Wiley Online Library
Bruton's tyrosine kinase (BTK) is a TEC kinase with a multifaceted role in B‐cell biology and
function, highlighted by its position as a critical component of the B‐cell receptor signalling …
function, highlighted by its position as a critical component of the B‐cell receptor signalling …
The development of Bruton's tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review
C Liang, D Tian, X Ren, S Ding, M Jia, M **n… - European journal of …, 2018 - Elsevier
Bruton's tyrosine kinase (BTK) has emerged as a promising drug target for multiple
diseases, particularly haematopoietic malignancies and autoimmune diseases related to B …
diseases, particularly haematopoietic malignancies and autoimmune diseases related to B …
Tyrosine kinases in autoimmune and inflammatory skin diseases
Tyrosine kinases relay signals from diverse leukocyte antigen receptors, innate immune
receptors, and cytokine receptors, and therefore mediate the recruitment and activation of …
receptors, and cytokine receptors, and therefore mediate the recruitment and activation of …