The complex association between COPD and COVID-19

NT Awatade, PAB Wark, ASL Chan… - Journal of Clinical …, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is significant cause of morbidity and
mortality worldwide. There is mounting evidence suggesting that COPD patients are at …

Electronic cigarettes: Modern instruments for toxic lung delivery and posing risk for the development of chronic disease

KD McAlinden, W Lu, MS Eapen, SS Sohal - The International Journal of …, 2021 - Elsevier
Following the emergence of electronic cigarette, or va** product use associated lung
injury (EVALI) in 2019 in the US, regulation of e-cigarettes has become globally tighter and …

Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population

M Chamnanphon, M Pongpanich, TB Suttichet… - Journal of human …, 2022 - nature.com
Host genetic factors have been shown to play a role in SARs-CoV-2 infection in diverse
populations. However, the genetic landscape differs among various ethnicities; therefore, we …

SARS-CoV-2 (COVID-19) adhesion site protein upregulation in small airways, type 2 pneumocytes, and alveolar macrophages of smokers and COPD–possible …

SJ Brake, MS Eapen, KD McAlinden… - … Journal of Chronic …, 2022 - Taylor & Francis
Background Smokers and patients with COPD are highly susceptible to SARS-CoV-2
infection, leading to severe COVID-19. Methods This cross-sectional study involved resected …

COVID-19: a pandemic converged with global tobacco epidemic and widespread va**—state of the evidence

A Besaratinia - Carcinogenesis, 2021 - academic.oup.com
This review highlights the convergence of three global health challenges at a crossroad
where the pandemic of coronavirus disease 2019 (COVID-19) meets the tobacco epidemic …

Clinical features and mechanistic insights into drug repurposing for combating COVID-19

P Asrani, K Tiwari, MS Eapen, KD McAlinden… - … International Journal of …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged from Wuhan in
China before it spread to the entire globe. It causes coronavirus disease of 2019 (COVID-19) …

Knowledge of SARS-CoV-2 epitopes and population HLA types is important in the design of COVID-19 vaccines

R Lani, NA Senin, S AbuBakar, P Hassandarvish - Vaccines, 2022 - mdpi.com
The COVID-19 pandemic has caused extensive loss of lives and economic hardship. In
response, infectious disease experts and vaccine developers promptly responded by …

Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease

Y Peng, ZN Wang, SY Chen, AR Xu… - … of Physiology-Lung …, 2022 - journals.physiology.org
Accumulating evidence has confirmed that chronic obstructive pulmonary disease (COPD) is
a risk factor for development of severe pathological changes in the peripheral lungs of …

Ligand-bound integrin αvβ6 internalisation and trafficking

A Meecham, LC Cutmore, P Protopapa… - Frontiers in cell and …, 2022 - frontiersin.org
The integrin αvβ6 is expressed at low levels in most normal healthy tissue but is very often
upregulated in a disease context including cancer and fibrosis. Integrins use endocytosis …