[HTML][HTML] Industrializing AI/ML during the end-to-end drug discovery process
Drug discovery aims to select proper targets and drug candidates to address unmet clinical
needs. The end-to-end drug discovery process includes all stages of drug discovery from …
needs. The end-to-end drug discovery process includes all stages of drug discovery from …
The regulatory role of tRNA-derived small RNAs in the prognosis of gastric cancer
X Shen, S Xu, Z Zheng, W Liang, J Guo - Cellular Signalling, 2025 - Elsevier
In recent years, tRNA-derived small RNAs (tsRNAs) including tRNA-derived stress-induced
RNAs (tiRNAs) and tRNA-derived fragments (tRFs), with specific structure and enriched in …
RNAs (tiRNAs) and tRNA-derived fragments (tRFs), with specific structure and enriched in …
[HTML][HTML] Aquilaria crassna Extract Exerts Neuroprotective Effect against Benzo[a]pyrene-Induced Toxicity in Human SH-SY5Y Cells: An RNA-Seq-Based …
N Pattarachotanant, S Sukjamnong, P Rangsinth… - Nutrients, 2024 - mdpi.com
Benzo [a] pyrene (B [a] P) is known to inhibit neurodifferentiation and induce
neurodegeneration. Agarwood or Aquilaria crassna (AC), a plant with health-promoting …
neurodegeneration. Agarwood or Aquilaria crassna (AC), a plant with health-promoting …
Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2
Why individuals with Down syndrome (DS) are more susceptible to SARS-CoV-2–induced
neuropathology remains elusive. Choroid plexus (ChP) plays critical roles in barrier function …
neuropathology remains elusive. Choroid plexus (ChP) plays critical roles in barrier function …
Cerebrospinal fluid protein biomarker discovery in CLN3
AN Dang Do, DE Sleat, K Campbell… - Journal of Proteome …, 2023 - ACS Publications
Syndromic CLN3-Batten is a fatal, pediatric, neurodegenerative disease caused by variants
in CLN3, which encodes the endolysosomal transmembrane CLN3 protein. No approved …
in CLN3, which encodes the endolysosomal transmembrane CLN3 protein. No approved …
[HTML][HTML] Protocol for generating embedding-free brain organoids enriched with oligodendrocytes
In response to the scarcity of advanced in vitro models dedicated to human CNS white
matter research, we present a protocol to generate neuroectoderm-derived embedding-free …
matter research, we present a protocol to generate neuroectoderm-derived embedding-free …
[HTML][HTML] Cerebrospinal Fluid Proteome Map Reveals Molecular Signatures of Reversible Cerebral Vasoconstriction Syndrome
JC Yang, SP Chen, YF Wang, CH Chang… - Molecular & Cellular …, 2024 - Elsevier
Reversible cerebral vasoconstriction syndrome (RCVS) is a complex neurovascular disorder
characterized by repetitive thunderclap headaches and reversible cerebral vasoconstriction …
characterized by repetitive thunderclap headaches and reversible cerebral vasoconstriction …
CH25H Promotes Autophagy and Regulates the Malignant Progression of Laryngeal Squamous Cell Carcinoma Through the PI3K‐AKT Pathway
Z ** human brain and provide a
compelling, cutting-edge platform for disease modeling and large-scale genomic and drug …
compelling, cutting-edge platform for disease modeling and large-scale genomic and drug …
[PDF][PDF] A Roadmap for Selecting and Utilizing Optimal Features in scRNA Sequencing Data Analysis for Stem Cell Research: A Comprehensive Review
Stem cells and the cells they produce are unique because they vary from one cell to another.
Traditional methods of studying cells often overlook these differences. However, the …
Traditional methods of studying cells often overlook these differences. However, the …