Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

The class Kinetoplastea encompasses both free-living and parasitic species from a wide
range of hosts. Several representatives of this group are responsible for severe human …

AlphaFold2 and RoseTTAfold represent a transformative advance for predicting protein
structure. They are able to make very high-quality predictions given a high-quality alignment …

Trypanosomatids are a group of kinetoplastid parasites including some of great public
health importance, causing debilitating and life-long lasting diseases that affect more than …

Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the
three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses …

Background As a result of evolution, the biology of triatomines must have been significantly
adapted to accommodate trypanosome infection in a complex network of vector-vertebrate …

Pathogens have evolved mechanisms to modulate host cell functions and avoid recognition
and destruction by the host damage response. For many years, researchers have focused …

Trypanosoma rangeli and Trypanosoma cruzi are generalist trypanosomes sharing a wide
range of mammalian hosts; they are transmitted by triatomine bugs, and are the only …

This review is dedicated to the memory of Professor Sir Vincent B. Wigglesworth (VW) in
recognition of his many pioneering contributions to insect physiology which, even today …

Trypanosoma cruzi, a zoonotic kinetoplastid protozoan parasite, is the causative agent of
American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex …