The human plasma proteome holds the promise of a revolution in disease diagnosis and
therapeutic monitoring provided that major challenges in proteomics and related disciplines …

The quantification of differences between two or more physiological states of a biological
system is among the most important but also most challenging technical tasks in proteomics …

The field of proteomics is built on technologies to analyze large numbers of proteins—ideally
the entire proteome—in the same experiment. Mass spectrometry (MS) has been …

In this paper, we report a novel, stable-isotope labeling strategy for quantitative proteomics
that uses a simple reagent, formaldehyde, to globally label the N-terminus and ε-amino …

The evolution of mass spectrometry–based proteomic technologies has advanced our
understanding of the complex and dynamic nature of proteomes while concurrently …

Proteomics can be defined as the systematic analysis of proteins for their identity, quantity
and function. In contrast to a cell's static genome, the proteome is both complex and …

A new method is presented for quantifying proteomic and metabolomic profile data by liquid
chromatography− mass spectrometry (LC− MS) with electrospray ionization. This …

Since immobilized metal ion affinity chromatography (IMAC) was first introduced, several
variants of this method and many other metal affinity-based techniques have been devised …

Large-scale genomics has enabled proteomics by creating sequence infrastructures that
can be used with mass spectrometry data to identify proteins. Although protein sequences …

Common strategies employed for general protein detection include organic dye, silver stain,
radiolabeling, reverse stain, fluorescent stain, chemiluminescent stain and mass …