X-ray crystal structures for the soluble amino-terminal and ligand-binding domains of
glutamate receptor ion channels, combined with a 3.6-Å-resolution structure of the full-length …

Filamins (FLN) are large dimeric proteins that cross-link actin and work as important
scaffolds in human cells. FLNs consist of an N-terminal actin-binding domain followed by 24 …

Ionotropic glutamate receptors (iGluRs) mediate most excitatory neurotransmission in the
central nervous system and function by opening their ion channel in response to binding of …

Ionotropic glutamate receptors (iGluRs) are ligand‐gated ion channels that open their ion‐
conducting pores in response to the binding of agonist glutamate. In recent years, significant …

Nano-biotechnology crosses the boundaries between physics, biochemistry and
bioengineering, and has profound implications for the biomedical engineering industry. This …

Atomistic molecular dynamics simulations were performed with 13 non-peptidic
neurotransmitters (NTs) in three different membrane environments. The results provide …

The N-methyl-D-aspartate receptor (NMDAR) is a member of the glutamate receptor family
of proteins and is responsible for excitatory transmission. Activation of the receptor is thought …

The failure of default scoring functions to ensure virtual screening enrichment is a persistent
problem for the molecular docking algorithms used in structure-based drug discovery. To …

AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and
are implicated in numerous neurological diseases. Ionic currents through AMPA receptor …