Polyamines are primordial polycations found in most cells and perform different functions in
different organisms. Although polyamines are mainly known for their essential roles in cell …

Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Leishmaniasis is a neglected vector-borne tropical infection considered to be a disease of
the poor. Concentrated in poverty-stricken countries within Southeast Asia, East Africa, and …

Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

Leishmania, a protozoan parasite, is responsible for the occurrence of leishmaniasis, a
disease that is prevalent in tropical regions. Visceral Leishmaniasis (VL), also known as kala …

The interaction between host and pathogen decidedly shapes the outcome of an infection,
thus understanding this interaction is critical to the treatment of a pathogen-induced …

Polyamine biosynthesis enzymes are promising drug targets for the treatment of
leishmaniasis, Chagas' disease and African slee** sickness. Arginase, which is a …

Auranofin is a gold (I)-containing drug in clinical use as an antiarthritic agent. Recent studies
showed that auranofin manifests interesting antiparasitic actions very likely arising from …

Protozoan parasites of the Leishmania genus are the causative agents of leishmaniasis, a
group of neglected tropical diseases whose clinical manifestations vary depending on the …

Neutralization or deletion of tumor necrosis factor (TNF) causes loss of control of intracellular
pathogens in mice and humans, but the underlying mechanisms are incompletely …