Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Astrocytes are predominant glial cells that tile the central nervous system and participate in
well-established functional and morphological interactions with neurons, blood vessels, and …

Astrocytic receptors influence cognitive function and can promote behavioral deficits in
disease. These effects may vary based on variables such as biological sex, but it is not …

Astrocytes are increasingly appreciated to possess underestimated and important roles in
modulating neuronal circuits. Astrocytes in striatum can regulate dopamine transmission by …

The traditional view of glial cells as mere supportive tissue has shifted, due to advances in
technology and theoretical conceptualization, to include a diversity of other functions, such …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective
degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in …

Abstract Background Patients with Alzheimer's Disease (AD) frequently suffer from
comorbidities such as type 2 diabetes mellitus (T2DM), accompanied by shared common …

Updating behavior based on feedback from the environment is a crucial means by which
organisms learn and develop optimal behavioral strategies1–3. Norepinephrine (NE) …

Astrocytes, which are increasingly recognized as pivotal constituents of brain circuits
governing a wide range of functions, express GABA transporter 3 (Gat3), an astrocyte …

Astrocyte dysfunctions have long been implicated in psychiatric and cognitive disorders, yet
the precise mechanisms underlying this association remain elusive. Here, we show that …