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Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis
M Tan, Y Yin, X Ma, J Zhang, W Pan, M Tan… - Cell Death & …, 2023 - nature.com
The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …
Mitochondrial dysfunction and oxidative stress in heart disease
Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players
in molecular signaling and cell fate determination through reactive oxygen species (ROS) …
in molecular signaling and cell fate determination through reactive oxygen species (ROS) …
Ischemic heart disease pathophysiology paradigms overview: from plaque activation to microvascular dysfunction
Ischemic heart disease still represents a large burden on individuals and health care
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …
Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week
Many treatments have been identified that confer robust cardioprotection in experimental
animal models of acute ischemia and reperfusion injury. However, translation of these …
animal models of acute ischemia and reperfusion injury. However, translation of these …
Reactive oxygen species scavenging nanomedicine for the treatment of ischemic heart disease
Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …
The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress
Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …
Rationale for the use of N‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19
COVID‐19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular
alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a …
alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a …
N-Acetylcysteine (NAC): Impacts on Human Health
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …
Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development
L Wilde, M Roche, M Domingo-Vidal, K Tanson… - Seminars in …, 2017 - Elsevier
abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
Optimized treatment of ST-elevation myocardial infarction: the unmet need to target coronary microvascular obstruction as primary treatment goal to further improve …
Primary percutaneous coronary intervention is nowadays the preferred reperfusion strategy
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …