[HTML][HTML] The canonical Notch signaling pathway: unfolding the activation mechanism
Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
Trafficking and proteolytic processing of APP
C Haass, C Kaether… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …
The secretases: enzymes with therapeutic potential in Alzheimer disease
The amyloid hypothesis has yielded a series of well-validated candidate drug targets with
potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in …
potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in …
The mechanism of γ‐secretase dysfunction in familial Alzheimer disease
The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor
protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD …
protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD …
The many substrates of presenilin/γ-secretase
A Haapasalo, DM Kovacs - Journal of Alzheimer's disease, 2011 - content.iospress.com
The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
γ-Secretase directly sheds the survival receptor BCMA from plasma cells
SA Laurent, FS Hoffmann, PH Kuhn, Q Cheng… - Nature …, 2015 - nature.com
Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-
bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ …
bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ …
Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process
B De Strooper - Physiological reviews, 2010 - journals.physiology.org
Alzheimer disease is characterized by the accumulation of abnormally folded protein
fragments, ie, amyloid beta peptide (Aβ) and tau that precipitate in amyloid plaques and …
fragments, ie, amyloid beta peptide (Aβ) and tau that precipitate in amyloid plaques and …
Proteolytic processing of Alzheimer's β‐amyloid precursor protein
H Zhang, Q Ma, Y Zhang, H Xu - Journal of Neurochemistry …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract β‐Amyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …
[HTML][HTML] Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
H Steiner, A Fukumori, S Tagami, M Okochi - Cell Stress, 2018 - ncbi.nlm.nih.gov
Alzheimers disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
Regulated intramembrane proteolysis–lessons from amyloid precursor protein processing
SF Lichtenthaler, C Haass… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 117, 779–796. Abstract Regulated intramembrane proteolysis (RIP)
controls the communication between cells and the extracellular environment. RIP is …
controls the communication between cells and the extracellular environment. RIP is …