OBJECTIVE: To summarize the role of reactive oxygen species (ROS) in the
pathophysiology of human reproduction. DESIGN: Review of literature. SETTING: Fertility …

At present infertility is affecting about 15% of couples and male factor is responsible for
almost 50% of infertility cases. Oxidative stress, due to enhanced Reactive Oxygen Species …

We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a
highly compact and complex structure and is capable of decondensation—features that must …

OBJECTIVE: To review the mechanisms responsible for DNA fragmentation in human
sperm, including those occurring during spermatogenesis and transport through the …

In Westernized societies, average consumption of n-6 polyunsaturated fatty acids (PUFAs)
far exceeds nutritional requirements. The ratio of n-6 to n-3 PUFAs is generally> 10: 1 …

Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for
male fertility evaluation. While its detrimental implications on sperm function were …

Extensive research in our center at the Cleveland Clinic indicates that the seminal oxidative
stress test has diagnostic and prognostic capabilities beyond those of conventional tests of …

Abstract Background Between 30% and 80% of patients with male infertility produce
excessive reactive oxygen species (ROS) in their ejaculate even though the cause of male …

DNA fragmentation is an important factor in the aetiology of male infertility. However, it is still
underevaluated and its inclusion in routine semen analysis is debated. DNA fragmentation …