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Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Pharmacological significance of nitrogen-containing five and six-membered heterocyclic scaffolds as potent cholinesterase inhibitors for drug discovery
N-heterocycles are crucial due to their biological, chemical, and practical significance. They
are heavily investigated in biological processes involving anticancer, anti-inflammatory …
are heavily investigated in biological processes involving anticancer, anti-inflammatory …
[HTML][HTML] Advancement of chitin and chitosan as promising biomaterials
MM Al-Rooqi, MM Hassan, Z Moussa, RJ Obaid… - Journal of Saudi …, 2022 - Elsevier
Biopolymers like cellulose, polysaccharides, chitosan, starch, chitin, and alginates have
sparked an increasing curiosity in creating natural replacements for synthetic polymers …
sparked an increasing curiosity in creating natural replacements for synthetic polymers …
A new class of anticancer activity with computational studies for a novel bioactive aminophosphonates based on pyrazole moiety
The present study involves synthesis a new series of α-aminophosphonates 2a-f and 4a-d
derivatives in good yield with a simple workup via Kabachnik-Fields reaction in the presence …
derivatives in good yield with a simple workup via Kabachnik-Fields reaction in the presence …
Discovery and optimization of 2, 3-diaryl-1, 3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity
Several studies have indicated the potential therapeutic outcomes of combining selective
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …
New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights
An efficient atom-economical synthetic protocol to access new imidazole-based N-
phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized …
phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized …
The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids
P Zhang, C Shi, T Dong, J Song… - Future Medicinal Chemistry, 2024 - Taylor & Francis
Cancer as a devastating malignancy, seriously threatens human life and health, but most
chemotherapeutics have long been criticized for unsatisfactory therapeutic efficacy due to …
chemotherapeutics have long been criticized for unsatisfactory therapeutic efficacy due to …
Design, synthesis, molecular docking, ADMET studies, and biological activity evaluation of new 2-({[3-aryl-1, 2, 4-oxadiazol-5-yl) methyl] thio}-1H-benzimidazoles and …
M Sharaf, AH Moustafa, RJ Obaid… - Journal of Molecular …, 2024 - Elsevier
Aryl amidoximes are active binucleophilic compounds used as a powerful and versatile
reagent in synthesizing diverse heterocyclic compounds with pharmacological interest …
reagent in synthesizing diverse heterocyclic compounds with pharmacological interest …
Antibacterial properties and computational insights of potent novel linezolid-based oxazolidinones
The mounting evidence of bacterial resistance against commonly prescribed antibiotics
warrants the development of new antibacterial drugs on an urgent basis. Linezolid, an …
warrants the development of new antibacterial drugs on an urgent basis. Linezolid, an …
Fluorene and Fluorenone Unnatural Amino Acid Motifs via Diastereoselective Pd(II)‐Catalyzed sp3C−H Functionalization
This paper reports the construction of racemic and enantiopure (D‐and L‐) fluorene and
fluorenone‐based novel unnatural amino acid derivatives. The Pd (II)‐catalyzed bidentate …
fluorenone‐based novel unnatural amino acid derivatives. The Pd (II)‐catalyzed bidentate …