Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

RJ Obaid, N Naeem, EU Mughal, MM Al-Rooqi… - RSC …, 2022 - pubs.rsc.org
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …

Pharmacological significance of nitrogen-containing five and six-membered heterocyclic scaffolds as potent cholinesterase inhibitors for drug discovery

RJ Obaid, EU Mughal, N Naeem, MM Al-Rooqi… - Process …, 2022 - Elsevier
N-heterocycles are crucial due to their biological, chemical, and practical significance. They
are heavily investigated in biological processes involving anticancer, anti-inflammatory …

[HTML][HTML] Advancement of chitin and chitosan as promising biomaterials

MM Al-Rooqi, MM Hassan, Z Moussa, RJ Obaid… - Journal of Saudi …, 2022 - Elsevier
Biopolymers like cellulose, polysaccharides, chitosan, starch, chitin, and alginates have
sparked an increasing curiosity in creating natural replacements for synthetic polymers …

A new class of anticancer activity with computational studies for a novel bioactive aminophosphonates based on pyrazole moiety

MH Baren, SA Ibrahim, MM Al-Rooqi, SA Ahmed… - Scientific Reports, 2023 - nature.com
The present study involves synthesis a new series of α-aminophosphonates 2a-f and 4a-d
derivatives in good yield with a simple workup via Kabachnik-Fields reaction in the presence …

Discovery and optimization of 2, 3-diaryl-1, 3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity

AM Shawky, FA Almalki, AN Abdalla… - European Journal of …, 2023 - Elsevier
Several studies have indicated the potential therapeutic outcomes of combining selective
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …

New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights

MS Malik, RI Alsantali, QMS Jamal, ZS Seddigi… - Frontiers in …, 2022 - frontiersin.org
An efficient atom-economical synthetic protocol to access new imidazole-based N-
phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized …

The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids

P Zhang, C Shi, T Dong, J Song… - Future Medicinal Chemistry, 2024 - Taylor & Francis
Cancer as a devastating malignancy, seriously threatens human life and health, but most
chemotherapeutics have long been criticized for unsatisfactory therapeutic efficacy due to …

Design, synthesis, molecular docking, ADMET studies, and biological activity evaluation of new 2-({[3-aryl-1, 2, 4-oxadiazol-5-yl) methyl] thio}-1H-benzimidazoles and …

M Sharaf, AH Moustafa, RJ Obaid… - Journal of Molecular …, 2024 - Elsevier
Aryl amidoximes are active binucleophilic compounds used as a powerful and versatile
reagent in synthesizing diverse heterocyclic compounds with pharmacological interest …

Antibacterial properties and computational insights of potent novel linezolid-based oxazolidinones

MS Malik, S Faazil, MA Alsharif, QM Sajid Jamal… - Pharmaceuticals, 2023 - mdpi.com
The mounting evidence of bacterial resistance against commonly prescribed antibiotics
warrants the development of new antibacterial drugs on an urgent basis. Linezolid, an …

Fluorene and Fluorenone Unnatural Amino Acid Motifs via Diastereoselective Pd(II)‐Catalyzed sp3C−H Functionalization

S Banga, SA Babu - European Journal of Organic Chemistry, 2024 - Wiley Online Library
This paper reports the construction of racemic and enantiopure (D‐and L‐) fluorene and
fluorenone‐based novel unnatural amino acid derivatives. The Pd (II)‐catalyzed bidentate …