The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial
metabolites and their availability in the gut and other organs is determined by environmental …

Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2
diabetes,. Previous metagenomic studies have described the characteristics of gut …

Metagenomic assembly enables new organism discovery from microbial communities, but it
can only capture few abundant organisms from most metagenomes. Here we present …

The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …

The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

Associations between age and the human microbiota are robust and reproducible. The
microbial composition at several body sites can predict human chronological age relatively …

Human skin is the largest organ and serves as the first line of defense against environmental
factors. The human microbiota is defined as the total microbial community that coexists in the …