Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

The genetics of Plasmodium as an intracellular, mostly haploid, sexually reproducing,
eukaryotic organism with a complex life cycle, presents unprecedented challenges in …

In vitro evolution of drug resistance is a powerful approach for identifying antimalarial
targets, however, key obstacles to eliciting resistance are the parasite inoculum size and …

Understanding the relatedness of individuals within or between populations is a common
goal in biology. Increasingly, relatedness features in genetic epidemiology studies of …

Short tandem repeats (STRs) are highly informative genetic markers that have been used
extensively in population genetics analysis. They are an important source of genetic …

Determining the genetic basis of fitness is central to understanding evolution and
transmission of microbial pathogens. In human malaria parasites (Plasmodium falciparum) …

Research efforts to combat antimalarial drug resistance rely on quick, robust, and sensitive
methods to genetically characterize Plasmodium falciparum parasites. We developed a …

Malaria symptoms are caused by the development of the parasites within the blood of an
infected host. Bulk RNA sequencing (RNA-seq) of infected blood can reveal interactions …

Population genomics of bulk malaria infections is unable to examine intrahost evolution;
therefore, most work has focused on the role of recombination in generating genetic …