Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of
axons,,–. Here we show that a crush injury to the spinal cord in neonatal mice leads to scar …

A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI),
but robust functional restoration has been elusive. Whether restoring neurological functions …

GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

Adult neurogenesis plays critical roles in maintaining brain homeostasis and responding to
neurogenic insults. However, the adult mammalian spinal cord lacks an intrinsic capacity for …

Aging is associated with increased prevalence of axonal injuries characterized by poor
regeneration and disability. However, the underlying mechanisms remain unclear. In our …