Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation
Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent
complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age …
complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age …
Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person
Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …
Caution,“normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021
An increasing interest in a healthy lifestyle raises questions about optimal body weight.
Evidently, it should be clearly discriminated between the standardised “normal” body weight …
Evidently, it should be clearly discriminated between the standardised “normal” body weight …
All around suboptimal health—a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and …
First two decades of the twenty-first century are characterised by epidemics of non-
communicable diseases such as many hundreds of millions of patients diagnosed with …
communicable diseases such as many hundreds of millions of patients diagnosed with …
Flavonoids as an effective sensitizer for anti-cancer therapy: Insights into multi-faceted mechanisms and applicability towards individualized patient profiles
Cost-efficacy of currently applied treatments is an issue in overall cancer management
challenging healthcare and causing tremendous economic burden to societies around the …
challenging healthcare and causing tremendous economic burden to societies around the …
Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine
Mitochondria are the “gatekeeper” in a wide range of cellular functions, signaling events, cell
homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to …
homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to …
Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care
Breast cancer incidence is actually the highest one among all cancers. Overall breast cancer
management is associated with challenges considering risk assessment and predictive …
management is associated with challenges considering risk assessment and predictive …
Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach
Due to the reactive medical approach applied to disease management, stroke has reached
an epidemic scale worldwide. In 2019, the global stroke prevalence was 101.5 million …
an epidemic scale worldwide. In 2019, the global stroke prevalence was 101.5 million …
[HTML][HTML] Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells–a potential contribution to the predictive, preventive …
A Mazurakova, L Koklesova, SH Csizmár… - Journal of Advanced …, 2024 - Elsevier
Background Cancer management faces multiple obstacles, including resistance to current
therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt …
therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt …
[HTML][HTML] DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury
Abstract Ischemia/reperfusion (I/R) injury is one of the most common etiologies in many
diseases. Retinal I/R leads to cytokine storm, resulting in tissue damage and cell death …
diseases. Retinal I/R leads to cytokine storm, resulting in tissue damage and cell death …