Drosophila melanogaster has been a key model in develo** our current understanding of
the molecular mechanisms of ageing. Of particular note is its role in establishing the …

Aging is a natural process of organismal decay that underpins the development of myriad
diseases and disorders. Extensive efforts have been made to understand the biology of …

Choosing the right nutrients to consume is essential to health and wellbeing across species.
However, the factors that influence these decisions are poorly understood. This is …

Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the
accuracy of translation, yet the physiological consequence of having fewer protein synthesis …

Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging
drug. We set out to address the fundamental question of how gut microbes and nutrition, key …

Recent research using Drosophila melanogaster has seen a resurgence in studies of
metabolism and physiology. This review focuses on major methods used to conduct this …

Ageing causes loss of function in tissues and organs, is accompanied by a chronic
inflammatory process and affects life‐and healthspan. Calorie restriction (CR) is a non …

The gut microbiome is increasingly recognized to play an important role in sha** the
health and fitness of animals, including humans. Drosophila is emerging as a valuable …

Animals must set behavioural priority in a context-dependent manner and switch from one
behaviour to another at the appropriate moment,–. Here we probe the molecular and …

Inorganic phosphate (Pi) is one of the essential molecules for life. However, little is known
about intracellular Pi metabolism and signalling in animal tissues. Following the observation …