Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

p53 has been studied intensively as a major tumour suppressor that detects oncogenic
events in cancer cells and eliminates them through senescence (a permanent non …

The function of p53 is best understood in response to genotoxic stress, but increasing
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …

Abstract Ataxia‐telangiectasia (A‐T) is an autosomal recessive primary immunodeficiency
(PID) disease that is caused by mutations in ataxia‐telangiectasia mutated (ATM) gene …

The Sestrins constitute a family of evolutionarily conserved stress-inducible proteins that
suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian …

Accumulation of DNA damage has been linked to the process of aging and to the onset of
age-related diseases including diabetes. Studies on progeroid syndromes have suggested …

Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …

The ataxia–telangiectasia mutated (ATM) protein kinase is best known for its role in the DNA
damage response, but recent findings suggest that it also functions as a redox sensor that …

We are increasingly aware that cellular metabolism plays a vital role in diseases such as
cancer, and that p53 is an important regulator of metabolic pathways. By transcriptional …

In the context of tumor suppression, p53 is an undisputedly critical protein. Functioning
primarily as a transcription factor, p53 helps fend off the initiation and progression of tumors …