Sex, hormones and cerebrovascular function: from development to disorder

A Collignon, L Dion-Albert, C Ménard… - Fluids and Barriers of …, 2024 - Springer
Proper cerebrovascular development and neurogliovascular unit assembly are essential for
brain growth and function throughout life, ensuring the continuous supply of nutrients and …

Unlocking hope: Therapeutic advances and approaches in modulating the WNT pathway for neurodegenerative diseases

N Faraji, N Ebadpour, M Abavisani, A Gorji - Molecular Neurobiology, 2024 - Springer
Neurodegenerative diseases (NDs) are conditions characterized by sensory, motor, and
cognitive impairments due to alterations in the structure and function of neurons in the …

[HTML][HTML] Metabolic dysfunction in Parkinson's Disease: unraveling the glucose–lipid connection

J Sian-Hulsmann, P Riederer, TM Michel - Biomedicines, 2024 - mdpi.com
Despite many years of research into the complex neurobiology of Parkinson's disease, the
precise aetiology cannot be pinpointed down to one causative agent but rather a multitude …

[HTML][HTML] An investigation on the alterations in Wnt signaling in ADHD across developmental stages

NM Walter, CMY Ohki, M Rickli, L Smigielski… - Neuroscience …, 2024 - Elsevier
The canonical Wnt signaling pathway plays a vital role in the developmental processes of
the Central Nervous System throughout both prenatal and postnatal stages, as well as in …

Diet-induced hyperhomocysteinemia causes sex-dependent deficiencies in offspring musculature and brain function

J Suszyńska-Zajczyk, Ł Witucki… - Frontiers in Cell and …, 2024 - frontiersin.org
Hyperhomocysteinemia (HHcy), characterized by elevated homocysteine (Hcy) levels, is a
known risk factor for cardiovascular, renal, and neurological diseases, as well as pregnancy …

Insights into Gastrointestinal Redox Dysregulation in a Rat Model of Alzheimer's Disease and the Assessment of the Protective Potential of D-galactose

J Homolak, K Varvaras, V Sciacca, A Babic Perhoc… - ACS …, 2024 - ACS Publications
Recent evidence suggests that the gut plays a vital role in the development and progression
of Alzheimer's disease (AD) by triggering systemic inflammation and oxidative stress. The …

[HTML][HTML] Psychiatric Disease as a Potential Risk Factor for Dementia: A Narrative Review

DW Hedges, M Chase, TJ Farrer, SD Gale - Brain Sciences, 2024 - mdpi.com
Neurodegenerative disease is a major global health problem with 150 million people
predicted to have dementia by 2050. Genetic factors, environmental factors, demographics …

Unravelling the joint genetic architecture between psychiatic and insulin-related traits in the general population

B Sakic, I Erdogan, G Fanelli, M Arenella, NR Mota… - medRxiv, 2024 - medrxiv.org
Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and
obsessive-compulsive disorder (OCD) are heritable disorders that frequently co-occur with …

My friend MIROSLAV: A Hackable Open-Source Hardware and Software Platform for High-Throughput Rodent Activity Monitoring in the Home Cage

D Virag, J Homolak, I Kodvanj, AM Vargantolić… - bioRxiv, 2024 - biorxiv.org
While conventional behavioural tests offer valuable insight into rodent behaviour in specific
paradigms, rodents spend most of their time in a safe, undisturbed environment–their home …

BGMDB: A curated database linking gut microbiota dysbiosis to brain disorders

K Shi, P Zhao, lin Li, Q Liu, Z Wu, Q He, J Yu - bioRxiv, 2024 - biorxiv.org
The gut microbiota plays a pivotal role in human health by modulating physiological
homeostasis and influencing the pathogenesis of various diseases. Recent studies have …