Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …

The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …

Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons.
They degenerate in multiple neurological disorders. However, their role in the pathogenesis …

Emerging data indicate that neurological complications occur as a consequence of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The blood–brain barrier …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …