Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

The current pandemic was caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). The quarantine period during corona virus disease 19 (COVID-19) outbreak …

Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …

Background In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for
several applications in the central nervous system (CNS), including targeting amyloid beta …

Accumulating evidence from animal and human studies supports the notion that physical
exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative …

Background Irisin is a novel exercise-induced myokine involved in the regulation of adipose
browning and thermogenesis. In this study, we investigated the potential role of irisin in …

Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in
modulation of metabolism and protection against obesity. These important functions are …

Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied
prognosis, chronic course, and duration of illness with reduced quality of life. One factor that …

Depressive disorders are common among the elderly. Major depressive disorder will be one
of the highest healthcare costs in middle and higher income countries by 2030. It is known …

Treatment of depression is hampered by the failure to identify distinct symptom profiles with
distinct pathophysiologies that differentially respond to distinct treatments. We posit that …