Fuelled by ATP hydrolysis, dyneins generate force and movement on microtubules in a
wealth of biological processes, including ciliary beating, cell division and intracellular …

Life implies movement. Most forms of movement in the living world are powered by tiny
protein machines known as molecular motors. Among the best known are motors that use …

Myosin V is a dimeric molecular motor that moves processively on actin, with the center of
mass moving∼ 37 nanometers for each adenosine triphosphate hydrolyzed. We have …

Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1
(HIV-1) isolates by binding an unusually dense cluster of carbohydrate moieties on the …

The general structural features of the motor region of myosin superfamily members are now
well established, as is a subset of the structural and kinetic transitions of the actin-myosin …

Cells use molecular motors, such as myosins, to move, position and segregate their
organelles. Class V myosins possess biochemical and structural properties that should …

Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …

Direct observation of the detailed conformational fluctuations of a single protein molecule en
route to its folded state has so far been realized only in silico. We have used single-molecule …

Cytoplasmic dynein is a minus-end-directed microtubule motor whose mechanism of
movement remains poorly understood. Here, we use optical tweezers to examine the force …