Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Acute kidney injury (AKI), defined as a rapid decrease in glomerular filtration rate, is a
common and devastating pathologic condition. AKI is associated with significant morbidity …

Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of
renal survival. Many different cell types contribute to TIF progression including tubular …

Epidemiologic, clinical, and molecular evidence suggest that aging is a major contributor to
the increasing incidence of acute kidney injury and chronic kidney disease. The aging …

The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites.
Renal drug transporters, which are primarily located in the renal proximal tubules, play an …

Palbociclib, ribociclib, and abemaciclib are inhibitors of the cyclin-dependent kinases 4 and
6 approved for the treatment of locally advanced or metastatic breast cancer. In this review …

This article provides a thorough overview of the biomarkers, pathophysiology, and molecular
pathways involved in the transition from acute kidney injury (AKI) and acute kidney disease …