Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

The autoimmune destruction of the pancreatic islet β cells is due to a targeted lymphocyte
attack. Different T cell subsets communicate with each other and with the insulin-producing β …

OBJECTIVE B lymphocytes play an important role in the immunopathogenesis of
autoimmune diabetes. We hypothesized that the altered B-cell subset phenotype is …

Regulatory T cells (Tregs) control organ-specific autoimmunity in a tissue antigen-specific
manner, yet little is known about their specificity in a natural repertoire. In this study, we used …

Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of insulin-
producing β cells. BDC2. 5 T cells in BDC2. 5 CD4+ T cell receptor transgenic Non-Obese …

The major complication in the treatment of hemophilia A is the development of neutralizing
antibodies (inhibitors) against factor VIII (FVIII). The current method for eradicating inhibitors …

Beyond their critical role in humoral immunity, B lymphocytes can employ a variety of
immunomodulatory mechanisms including expression of the apoptosis-inducing molecule …

Experiments with B cell-deficient (B−/−) mice indicate that a number of autoimmune
diseases require B cells in addition to T cells for their development. Using B−/− Non-obese …

Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease, although B cells also play
an important role in T1D development. Both T cell–and B cell–directed immunotherapies …

Aims/hypothesis Type 1 diabetes is a T cell-mediated autoimmune disease characterised by
the destruction of beta cells in the islets of Langerhans, resulting in deficient insulin …