Recombination is a prominent feature of meiosis in which it plays an important role in
increasing genetic diversity during inheritance. Additionally, in most organisms …

Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …

Meiotic crossovers (COs) have intriguing patterning properties, including CO interference,
the tendency of COs to be well-spaced along chromosomes, and heterochiasmy, the marked …

INTRODUCTION Diversity in the sequence of the human genome, arising from
recombinations and mutations, is fundamental to human evolution and human diversity …

Meiosis is an essential stage in gamete formation in all sexually reproducing organisms.
Studies of mutations in model organisms and of human haplotype patterns are leading to a …

Premature ovarian insufficiency (POI) is one form of female infertility, defined by loss of
ovarian activity before the age of 40 and characterized by amenorrhea (primary or …

The mechanisms regulating meiotic initiation in mammals are enigmatic. It is known that
retinoic acid (RA) signaling plays a pivotal role during meiotic initiation. STRA8, which is …

Aneuploidy is the most common chromosome abnormality in humans, and is the leading
genetic cause of miscarriage and congenital birth defects. Since the identification of the first …

The synaptonemal complex (SC) is a meiosis-specific scaffold that links homologous
chromosomes from end to end during meiotic prophase and is required for the formation of …

Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are
repaired by recombination from homologous chromosomes (homologues). In a wide variety …