TRP channel proteins constitute a large and diverse family of proteins that are expressed in
many tissues and cell types. This family was designated TRP because of a spontaneously …

Drosophila visual transduction is the fastest known G-protein-coupled signaling cascade
and has therefore served as a genetically tractable animal model for characterizing rapid …

Many intracellular signaling pathways are initiated by a simple reaction, the hydrolysis of
phosphatidylinositol 4, 5-bisphosphate (PIP2) 1 (1), which results in a transient rise in the …

Highlights•Drosophila phototransduction uses canonical Gq/PLC/TRP channel cascade.•
Photoreceptors respond to single photons 10–100× faster than vertebrate …

The O-linked-N-acetylglucosamine (O-GlcNAc) modification of cytoplasmic and nuclear
proteins regulates basic cellular functions and is involved in the aetiology of diabetes and …

The wiring patterns among various types of neurons via specific synaptic connections are
the basis of functional logic employed by the brain for information processing. This study …

Fly eyes have been a useful biological system in which fundamental principles of sensory
signaling have been elucidated. The physiological optics of the fly compound eye, which …

There is a rapidly growing interest in the family of transient receptor potential (TRP)
channels because TRP channels are not only important for many sensory systems, but they …

▪ Abstract In Drosophila photoreceptors, the light-sensitive current is mediated downstream
of phospholipase C by TRP (transient receptor potential) channels. Recent evidence …

Phosphoinositides are key regulators of a large number of diverse cellular processes that
include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and …