Structural biology and molecular pharmacology of voltage-gated ion channels
Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …
permeate ions across the cell membrane in response to changes in membrane potential …
Cryo-EM structure of human voltage-gated sodium channel Nav1.6
Voltage-gated sodium channel Nav1. 6 plays a crucial role in neuronal firing in the central
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …
[HTML][HTML] MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants
I Hasballa, D Maggi - International Journal of Molecular Sciences, 2024 - mdpi.com
Maturity-onset diabetes of the young (MODY) represents the most frequent form of
monogenic diabetes mellitus (DM), currently classified in 14 distinct subtypes according to …
monogenic diabetes mellitus (DM), currently classified in 14 distinct subtypes according to …
Structural basis for human Cav3.2 inhibition by selective antagonists
The Cav3. 2 subtype of T-type calcium channels has been targeted for develo**
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …
Voltage-dependent G-protein regulation of CaV2.2 (N-type) channels
M Nilsson, K Wang, T Mínguez-Viñas, M Angelini… - Science …, 2024 - science.org
How G proteins inhibit N-type, voltage-gated, calcium-selective channels (CaV2. 2) during
presynaptic inhibition is a decades-old question. G proteins Gβγ bind to intracellular CaV2. 2 …
presynaptic inhibition is a decades-old question. G proteins Gβγ bind to intracellular CaV2. 2 …
Structural basis for human Cav1. 2 inhibition by multiple drugs and the neurotoxin calciseptine
Ca v 1.2 channels play crucial roles in various neuronal and physiological processes. Here,
we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with …
we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with …
Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3
Y Gao, S Xu, X Cui, H Xu, Y Qiu, Y Wei, Y Dong… - Nature …, 2023 - nature.com
High-voltage-activated R-type CaV2. 3 channel plays pivotal roles in many physiological
activities and is implicated in epilepsy, convulsions, and other neurodevelopmental …
activities and is implicated in epilepsy, convulsions, and other neurodevelopmental …
Native MS-guided lipidomics to define endogenous lipid microenvironments of eukaryotic receptors and transporters
D Wu, H Tang, X Qiu, S Song, S Chen, CV Robinson - Nature Protocols, 2024 - nature.com
The mammalian membrane is composed of various eukaryotic lipids interacting with
extensively post-translationally modified proteins. Probing interactions between these …
extensively post-translationally modified proteins. Probing interactions between these …
Pathology of pain and its implications for therapeutic interventions
B Cao, Q Xu, Y Shi, R Zhao, H Li, J Zheng… - … and Targeted Therapy, 2024 - nature.com
Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …
health and economic burdens. Effective pain management is crucial for individuals suffering …
[HTML][HTML] Benzo [a] pyrene represses synaptic vesicle exocytosis by inhibiting P/Q-type calcium channels in hippocampal neurons
YK Kim, Y Eom, H Yoon, Y Lee, SH Lee - Ecotoxicology and Environmental …, 2023 - Elsevier
Humans are exposed to the common carcinogen benzo [a] pyrene (BaP) by ingesting
contaminated foods and water or inhaling polluted air. Given the enriched lipids and …
contaminated foods and water or inhaling polluted air. Given the enriched lipids and …