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Hepatic stellate cells in physiology and pathology
DR Kamm, KS McCommis - The Journal of physiology, 2022 - Wiley Online Library
Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …
Hepatic stellate cells as key target in liver fibrosis
T Higashi, SL Friedman, Y Hoshida - Advanced drug delivery reviews, 2017 - Elsevier
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …
than one million deaths annually via development of cirrhosis, although no antifibrotic …
Metabolic messengers: adiponectin
LG Straub, PE Scherer - Nature metabolism, 2019 - nature.com
Adiponectin, first described in the mid-1990s, is one of the most widely studied adipokines to
date. Studies of its regulation, biogenesis and physiological effects have yielded great …
date. Studies of its regulation, biogenesis and physiological effects have yielded great …
Nonalcoholic fatty liver disease: pathogenesis and disease spectrum
T Hardy, F Oakley, QM Anstee… - Annual review of …, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …
the Western world and is increasing owing to its close association with obesity and insulin …
Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management
T Marjot, A Moolla, JF Cobbold, L Hodson… - Endocrine …, 2020 - academic.oup.com
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
AP Rolo, JS Teodoro, CM Palmeira - Free radical biology and medicine, 2012 - Elsevier
The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
SL Friedman - Physiological reviews, 2008 - journals.physiology.org
The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …
Pathogenesis of liver fibrosis
V Hernandez-Gea, SL Friedman - Annual review of pathology …, 2011 - annualreviews.org
Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …
[PDF][PDF] Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
R Lomonaco, C Ortiz‐Lopez, B Orsak, A Webb… - …, 2012 - Wiley Online Library
The role of adipose tissue insulin resistance in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) remains unclear. To evaluate this, we measured in 207 patients with …
disease (NAFLD) remains unclear. To evaluate this, we measured in 207 patients with …
Evolving challenges in hepatic fibrosis
SL Friedman - Nature reviews Gastroenterology & hepatology, 2010 - nature.com
Continued elucidation of the mechanisms of hepatic fibrosis has yielded a comprehensive
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …