Oligodendrocytes in development, myelin generation and beyond
Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …
Oligodendrocyte development and plasticity
Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain
and spinal cord and migrate throughout the develo** central nervous system (CNS) …
and spinal cord and migrate throughout the develo** central nervous system (CNS) …
Origin and dynamics of oligodendrocytes in the develo** brain: Implications for perinatal white matter injury
E van Tilborg, CGM de Theije, M van Hal, N Wagenaar… - Glia, 2018 - Wiley Online Library
Infants born prematurely are at high risk to develop white matter injury (WMI), due to
exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the …
exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the …
The glial nature of embryonic and adult neural stem cells
Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …
supportive cells with an origin very different from that of neurons. New studies have shown …
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function
Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …
rather a distinct and heterogeneous population of glia with various functions in the …
Hedgehog signaling in animal development: paradigms and principles
Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …
signaling proteins have come to be recognized as key mediators of many fundamental …
Developmental genetics of vertebrate glial–cell specification
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous
system. These cells have diverse roles in the maintenance of neurological function. In the …
system. These cells have diverse roles in the maintenance of neurological function. In the …
Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
The developmental origin of oligodendrocyte progenitors (OLPs) in the forebrain has been
controversial. We now show, by Cre-lox fate map** in transgenic mice, that the first OLPs …
controversial. We now show, by Cre-lox fate map** in transgenic mice, that the first OLPs …
NG 2‐glia and their functions in the central nervous system
In the central nervous system, NG2‐glia represent a neural cell population that is distinct
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …
[HTML][HTML] Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are
coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on …
coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on …