Human cognitive abilities are generally thought to arise from cortical expansion over the
course of human brain evolution. In addition to increased neuron numbers, this cortical …

Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

The size and shape of dendrites and axons are strong determinants of neuronal information
processing. Our knowledge on neuronal structure and function is primarily based on brains …

Objective. We implemented computational models of human and rat cortical neurons for
simulating the neural response to cortical stimulation with electromagnetic fields. Approach …

The advanced cognitive capabilities of the human brain are often attributed to our recently
evolved neocortex. However, it is not known whether the basic building blocks of the human …

Synaptic transmission constitutes the primary mode of communication between neurons. It is
extensively studied in rodent but not human neocortex. We characterized synaptic …

Mammalian neocortex is a highly layered structure. Each layer is populated by distinct
subtypes of principal cells that are born at different times during development. While the …

Gene expression studies suggest that differential ion channel expression contributes to
differences in rodent versus human neuronal physiology. We tested whether h-channels …

It is generally assumed that human intelligence relies on efficient processing by neurons in
our brain. Although grey matter thickness and activity of temporal and frontal cortical areas …

We present detailed models of pyramidal cells from human neocortex, including models on
their excitatory synapses, dendritic spines, dendritic NMDA-and somatic/axonal Na+ spikes …