[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …
Revolutionizing drug formulation development: the increasing impact of machine learning
Over the past few years, the adoption of machine learning (ML) techniques has rapidly
expanded across many fields of research including formulation science. At the same time …
expanded across many fields of research including formulation science. At the same time …
[HTML][HTML] Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …
Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery–an update
SV Jermain, C Brough, RO Williams III - International journal of …, 2018 - Elsevier
Poor water-solubility remains a typical property of drug candidates in pharmaceutical
development pipelines today. Various processes have been developed to increase the …
development pipelines today. Various processes have been developed to increase the …
Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches
Spray drying is increasingly becoming recognized as an efficient drying and formulation
technique for pharmaceutical and biopharmaceutical processing. It offers significant …
technique for pharmaceutical and biopharmaceutical processing. It offers significant …
Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
Hydroxypropyl methylcellulose acetate succinate as an exceptional polymer for amorphous solid dispersion formulations: A review from bench to clinic
A Butreddy - European Journal of Pharmaceutics and …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) are a proven system for achieving a supersaturated
state of drug, in which the concentration of drug is greater than its crystalline solubility. The …
state of drug, in which the concentration of drug is greater than its crystalline solubility. The …
Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals–a comprehensive review
Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …
inadequate drug dissolution rates, is one of the most significant challenges that …
Co-amorphous solid dispersions for solubility and absorption improvement of drugs: Composition, preparation, characterization and formulations for oral delivery
The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …
However, due to thermodynamic instability and recrystallization tendencies during …
Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs
X Zhang, H **ng, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …
dissolution characteristics have been witnessed, which invokes great interest in enabling …