The mathematics of cancer: integrating quantitative models

PM Altrock, LL Liu, F Michor - Nature Reviews Cancer, 2015‏ - nature.com
Mathematical modelling approaches have become increasingly abundant in cancer
research. The complexity of cancer is well suited to quantitative approaches as it provides …

RNA interference in the clinic: challenges and future directions

CV Pecot, GA Calin, RL Coleman… - Nature Reviews …, 2011‏ - nature.com
Inherent difficulties with blocking many desirable targets using conventional approaches
have prompted many to consider using RNA interference (RNAi) as a therapeutic approach …

Nonlinear modelling of cancer: bridging the gap between cells and tumours

JS Lowengrub, HB Frieboes, F **, YL Chuang, X Li… - …, 2009‏ - iopscience.iop.org
Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

Three-dimensional multispecies nonlinear tumor growth—I: model and numerical method

SM Wise, JS Lowengrub, HB Frieboes… - Journal of theoretical …, 2008‏ - Elsevier
This is the first paper in a two-part series in which we develop, analyze, and simulate a
diffuse interface continuum model of multispecies tumor growth and tumor-induced …

Computational oncology—mathematical modelling of drug regimens for precision medicine

D Barbolosi, J Ciccolini, B Lacarelle, F Barlési… - Nature reviews Clinical …, 2016‏ - nature.com
Computational oncology is a generic term that encompasses any form of computer-based
modelling relating to tumour biology and cancer therapy. Mathematical modelling can be …

[کتاب][B] Multiscale modeling of cancer: an integrated experimental and mathematical modeling approach

V Cristini, J Lowengrub - 2010‏ - books.google.com
Mathematical modeling, analysis and simulation are set to play crucial roles in explaining
tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial …

Multiscale modelling and nonlinear simulation of vascular tumour growth

P Macklin, S McDougall, ARA Anderson… - Journal of mathematical …, 2009‏ - Springer
In this article, we present a new multiscale mathematical model for solid tumour growth
which couples an improved model of tumour invasion with a model of tumour-induced …

Frontiers in cancer nanomedicine: directing mass transport through biological barriers

M Ferrari - Trends in biotechnology, 2010‏ - cell.com
The physics of mass transport within body compartments and across biological barriers
differentiates cancers from healthy tissues. Variants of nanoparticles can be manufactured in …

Three-dimensional multispecies nonlinear tumor growth—II: tumor invasion and angiogenesis

HB Frieboes, F **, YL Chuang, SM Wise… - Journal of theoretical …, 2010‏ - Elsevier
We extend the diffuse interface model developed in Wise et al.(2008) to study nonlinear
tumor growth in 3-D. Extensions include the tracking of multiple viable cell species …

Computer simulation of glioma growth and morphology

HB Frieboes, JS Lowengrub, S Wise, X Zheng… - Neuroimage, 2007‏ - Elsevier
Despite major advances in the study of glioma, the quantitative links between intra-tumor
molecular/cellular properties, clinically observable properties such as morphology, and …