Abnormally increased hepatic gluconeogenesis is a significant contributor to hyperglycemia
in the fasting state in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance …

Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …

Gut microbiota dysbiosis is associated with the development of rheumatoid arthritis (RA).
Sinomenine (SIN) is an effective immunosuppressive and anti-inflammatory drug used for …

Non-alcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver
disease globally. It initiates with simple steatosis (NAFL) and can progress to the more …

Metabolic reprogramming is associated with resistance to antiangiogenic therapy in cancer.
However, its molecular mechanisms have not been clearly elucidated. Here, we identify the …

Abstract Background The Enoyl-CoA hydratase/isomerase family plays a crucial role in the
metabolism of tumors, being crucial for maintaining the energy balance and biosynthetic …

Cancer cells rely on heightened protein quality control mechanisms, including the ubiquitin-
proteosome system that is predominantly driven by ubiquitination comprising E1, E2, and E3 …

Background Domesticated pigs serve as an ideal animal model for biomedical research and
also provide the majority of meat for human consumption in China. Porcine intramuscular fat …

Aging is widely accepted as an independent risk factor for cardiovascular disease (CVD),
which contributes to increasing morbidity and mortality in the elderly population. Lysine β …

Background The metabolic flexibility of endothelial cells is linked to their phenotypic
plasticity. Frataxin is critical in determining the iron metabolism and fate of endothelial cells …