Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

With the development of smart devices and cloud computing, more and more public health
data can be collected from various sources and can be analyzed in an unprecedented way …

Age is a common risk factor in many diseases, but the molecular basis for this relationship is
elusive. In this study we identified four disease clusters from 116 diseases in UK Biobank …

In many applications, one is interested in determining which of the properties of a network
module change across conditions. For example, to validate the existence of a module, it is …

Background Multicomponent therapeutics offer bright prospects for the control of complex
diseases in a synergistic manner. However, finding ways to screen the synergistic …

Background MicroRNAs (miRNAs) are important post-transcriptional regulators that have
been demonstrated to play an important role in human diseases. Elucidating the …

Metabolomics is the latest state-of-the-art omics technology that provides a comprehensive
quantitative profile of metabolites. The metabolites are the cellular end products of metabolic …

Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …

A most challenging task for scientists that are involved in the study of ageing is the
development of a measure to quantify health status across populations and over time. In the …

Abstract In model organisms, over 2,000 genes have been shown to modulate aging, the
collection of which we call the 'gerontome'. Although some individual aging-related genes …