Inflammation, infection and venous thromboembolism
ME Colling, BE Tourdot, Y Kanthi - Circulation research, 2021 - Am Heart Assoc
The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …
recognized; yet, only in the last decades have we begun to understand the mechanisms …
How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
INTRODUCTION Mucosal barrier sites are continuously exposed to diverse environmental
stimuli, and the fine-tuning of mucosal tissue–specific immune responses is key to …
stimuli, and the fine-tuning of mucosal tissue–specific immune responses is key to …
Plasmin and plasminogen system in the tumor microenvironment: implications for cancer diagnosis, prognosis, and therapy
Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …
activation system is utilized by tumor cells in their unrelenting attack on the tissues …
A critical role for plasminogen in inflammation
SK Baker, S Strickland - Journal of Experimental Medicine, 2020 - rupress.org
Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory
response in mammals. Due to these roles in inflammation, plasminogen has been …
response in mammals. Due to these roles in inflammation, plasminogen has been …
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A
AW Strilchuk, WS Hur, P Batty, Y Sang… - Science Translational …, 2024 - science.org
Antifibrinolytic drugs are used extensively for on-demand treatment of severe acute
bleeding. Controlling fibrinolysis may also be an effective strategy to prevent or lessen …
bleeding. Controlling fibrinolysis may also be an effective strategy to prevent or lessen …
[HTML][HTML] Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID‐19: a single‐center prospective longitudinal study
Background Immunothrombosis and coagulopathy in the lung microvasculature may lead to
lung injury and disease progression in coronavirus disease 2019 (COVID‐19). We aim to …
lung injury and disease progression in coronavirus disease 2019 (COVID‐19). We aim to …
Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction
Implantation of biomaterials and medical devices in the body triggers the foreign body
reaction (FBR) which is characterized by macrophage fusion at the implant surface leading …
reaction (FBR) which is characterized by macrophage fusion at the implant surface leading …
[HTML][HTML] The role of glutathione in prevention of COVID-19 immunothrombosis: a review
I Glassman, N Le, M Mirhosseini… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Immunothrombosis has emerged as a dominant pathological process exacerbating
morbidity and mortality in acute-and long-COVID-19 infections. The hypercoagulable state is …
morbidity and mortality in acute-and long-COVID-19 infections. The hypercoagulable state is …
Extracellular Matrix in Ischemic Heart Disease, Part 4/4: JACC Focus Seminar
Myocardial ischemia and infarction, both in the acute and chronic phases, are associated
with cardiomyocyte loss and dramatic changes in the cardiac extracellular matrix (ECM). It …
with cardiomyocyte loss and dramatic changes in the cardiac extracellular matrix (ECM). It …