Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression

J Lasselin, M Lekander, S Benson, M Schedlowski… - Molecular …, 2021 - nature.com
Depression is one of the global leading causes of disability, but treatments remain limited
and classical antidepressants were found to be ineffective in a substantial proportion of …

Nutrigenomics, the microbiome, and gene-environment interactions: new directions in cardiovascular disease research, prevention, and treatment: a scientific …

JF Ferguson, H Allayee, RE Gerszten… - Circulation …, 2016 - Am Heart Assoc
Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked
to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple …

Role of n-3 polyunsaturated fatty acids in ameliorating the obesity-induced metabolic syndrome in animal models and humans

CW Huang, YS Chien, YJ Chen, KM Ajuwon… - International journal of …, 2016 - mdpi.com
The incidence of obesity and its comorbidities, such as insulin resistance and type II
diabetes, are increasing dramatically, perhaps caused by the change in the fatty acid …

Bioactive products formed in humans from fish oils1 [S]

C Skarke, N Alamuddin, JA Lawson, X Li… - Journal of lipid …, 2015 - ASBMB
Resolvins, maresins, and protectins can be formed from fish oils. These specialized pro-
resolving mediators (SPMs) have been implicated in the resolution of inflammation …

Omega-3 fatty acids and adipose tissue: inflammation and browning

NS Kalupahana, BL Goonapienuwala… - Annual Review of …, 2020 - annualreviews.org
White adipose tissue (WAT) and brown adipose tissue (BAT) are involved in whole-body
energy homeostasis and metabolic regulation. Changes to mass and function of these …

Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension …

R Uchio, K Muroyama, C Okuda-Hanafusa, K Kawasaki… - Nutrients, 2019 - mdpi.com
To investigate the effect of a hot water extract of C. longa L.(WEC) containing anti-
inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized …

Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?

D Vauzour, A Martinsen, S Layé - Neurochemistry International, 2015 - Elsevier
Neuroinflammatory processes are known to contribute to the cascade of events culminating
in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's …

Regulation of immune function in healthy adults: One-stop guide on the role of dietary fatty acids, gut microbiota-derived short chain fatty acids, and select …

D Patel, J Evanchuk, R Wang… - Applied Physiology …, 2023 - cdnsciencepub.com
The immune system requires an adequate supply of nutrients, although current dietary
recommendations may not account for optimal immune function in healthy adults. Nutrient …

Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases

PN Patel, RY Shah, JF Ferguson… - … thrombosis, and vascular …, 2015 - Am Heart Assoc
Inflammation is a fundamental feature of several complex cardiometabolic diseases. Indeed,
obesity, insulin resistance, metabolic dyslipidemia, and atherosclerosis are all closely linked …

Modulation of breast cancer risk biomarkers by high-dose omega-3 fatty acids: phase II pilot study in premenopausal women

CJ Fabian, BF Kimler, TA Phillips, JA Box… - Cancer prevention …, 2015 - AACR
Higher intakes of the omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) relative to the omega-6 arachidonic acid (AA) have been variably associated with …