Variability of vaccine responsiveness in early life
ME Pichichero - Cellular Immunology, 2023 - Elsevier
Vaccinations in early life elicit variable antibody and cellular immune responses, sometimes
leaving fully vaccinated children unprotected against life-threatening infectious diseases …
leaving fully vaccinated children unprotected against life-threatening infectious diseases …
Flagellin/NLRC4 pathway rescues NLRP3-inflammasome defect in dendritic cells from HIV-infected patients: perspective for new adjuvant in immunocompromised …
Introduction: NLRP3 inflammasome plays a key role in dendritic cells (DC) activation in
response to vaccine adjuvants, however we previously showed that it is not properly …
response to vaccine adjuvants, however we previously showed that it is not properly …
Variability of Vaccine Responsiveness in Young Children
ME Pichichero, L Xu, E Gonzalez… - The Journal of …, 2024 - academic.oup.com
Background Variability in vaccine responsiveness among young children is poorly
understood. Methods Nasopharyngeal secretions were collected in the first weeks of life for …
understood. Methods Nasopharyngeal secretions were collected in the first weeks of life for …
Variability in Vaccine Response and Trajectory in Early Childhood and Association With Demographic Variables, Antibiotic Exposure, and Infection Proneness
ME Pichichero, E Gonzalez, A Cox… - The Journal of …, 2025 - academic.oup.com
Introduction We sought to explore the variability of antibody responses to multiple vaccines
during early life in individual children, assess the trajectory of each child longitudinally …
during early life in individual children, assess the trajectory of each child longitudinally …
Prospective study of the innate cellular immune response in low vaccine responder children
N Surendran, T Nicolosi, R Kaur, M Morris… - Innate …, 2017 - journals.sagepub.com
We recently reported our findings from a longitudinal, prospective study where we identified
10% infants who were low vaccine responders (LVR) at age 9–12 mo following routine …
10% infants who were low vaccine responders (LVR) at age 9–12 mo following routine …
Computation of robust minimal intervention sets in multi-valued biological regulatory networks
Enabled by rapid advances in computational sciences, in silico logical modeling of complex
and large biological networks is more and more feasible making it an increasingly popular …
and large biological networks is more and more feasible making it an increasingly popular …
Functional Programming of Innate Immune Cells in Response to Bordetella pertussis Infection and Vaccination
J Gillard, E van Schuppen… - Pertussis Infection and …, 2019 - Springer
Despite widespread vaccination, B. pertussis remains one of the least controlled vaccine-
preventable diseases. Although it is well known that acellular and whole cell pertussis …
preventable diseases. Although it is well known that acellular and whole cell pertussis …
Respiratory infection-and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways
Background Infants with frequent viral and bacterial respiratory infections exhibit
compromised immunity to routine immunizations. They are also more likely to develop …
compromised immunity to routine immunizations. They are also more likely to develop …
Edione Cristina dos Reis 1*, Vinícius Nunes Cordeiro Leal 1, Jaíne Lima da Silva Soares 1, Fernanda Pereira Fernandes 1, Dhêmerson Souza de Lima 1, Bruna …
A Pontillo - Harnessing the Participation of Dendritic Cells in …, 2020 - books.google.com
MATERIALS AND METHODS Dendritic cells (DC) are a specialized professional antigen
presenting cells (APC) with unique capability to initiate and maintain primary immune …
presenting cells (APC) with unique capability to initiate and maintain primary immune …