Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

In addition to producing profound subjective effects following acute administration,
psychedelic compounds can induce beneficial behavioral changes relevant to the treatment …

The brain is the key organ of stress reactivity, co**, and recovery processes. Within the
brain, a distributed neural circuitry determines what is threatening and thus stressful to the …

The brain is the key organ of the response to stress because it determines what is
threatening and, therefore, potentially stressful, as well as the physiological and behavioral …

The ventral pallidum (VP) plays a critical role in the processing and execution of motivated
behaviors. Yet this brain region is often overlooked in published discussions of the …

The Papez circuit, first proposed by James Papez in 1937, is a circuit believed to control
memory and emotions, composed of the cingulate cortex, entorhinal cortex …

OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering
motivational strength and decreased ability to control the desire to obtain drugs. In this …

The brain is the central organ of stress and adaptation to stress because it perceives and
determines what is threatening, as well as the behavioral and physiological responses to the …

Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …