Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

The Hippo signaling pathway is a central growth control mechanism in multicellular
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …

The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

The molecular machinery that enables life has evolved in water, yet many of the organisms
around us are able to survive even extreme desiccation. Especially remarkable are single …

MALAT1 has previously been described as a metastasis-promoting long noncoding RNA
(lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

Background Metastatic colonization is one of the critical steps in tumor metastasis. A pre-
metastatic niche is required for metastatic colonization and is determined by tumor-stroma …

Numerous reports have elucidated the important participation of exosomes in the
communication between tumor cells and other cancer‐related cells including tumor …