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Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Mechanisms of ketamine and its metabolites as antidepressants
Treating major depression is a medical need that remains unmet by monoaminergic
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …
Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor
We show that the sex of human experimenters affects mouse behaviors and responses
following administration of the rapid-acting antidepressant ketamine and its bioactive …
following administration of the rapid-acting antidepressant ketamine and its bioactive …
Psychedelics and neural plasticity: therapeutic implications
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …
attitudes toward them are changing, and scientists are once again investigating the neural …
Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial
Ketamine has rapid-onset antidepressant activity in patients with treatment-resistant major
depression (TRD). The safety and tolerability of racemic ketamine may be improved if given …
depression (TRD). The safety and tolerability of racemic ketamine may be improved if given …
Nanomedomics
Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such
as inorganic, lipid, polymers, and protein nanoparticles have been widely developed for …
as inorganic, lipid, polymers, and protein nanoparticles have been widely developed for …
The molecular pathophysiology of depression and the new therapeutics
Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …
The abuse liability of ketamine: A sco** review of preclinical and clinical studies
While ketamine has been used clinically over the past decades, it has only been recently
shown to be a promising therapy for treatment-resistant depression (TRD). However …
shown to be a promising therapy for treatment-resistant depression (TRD). However …
Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis
Abstract (R, S)-ketamine (ketamine) and its enantiomer (S)-ketamine (esketamine) can
produce rapid and substantial antidepressant effects. However, individual response to …
produce rapid and substantial antidepressant effects. However, individual response to …
Narrative review: low-dose ketamine for Pain Management
A Riccardi, M Guarino, S Serra… - Journal of Clinical …, 2023 - mdpi.com
Pain is the leading cause of medical consultations and occurs in 50–70% of emergency
department visits. To date, several drugs have been used to manage pain. The clinical use …
department visits. To date, several drugs have been used to manage pain. The clinical use …