Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …

Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along
perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function …

The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as
nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system …

Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

The CNS is prone to heterogeneous insults of diverse etiologies that elicit multifaceted
responses. Acute and focal injuries trigger wound repair with tissue replacement. Diffuse …

Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …

Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

In addition to their many functions in the healthy central nervous system (CNS), astrocytes
respond to CNS damage and disease through a process called astrogliosis. For many …