Waddington's epigenetic landscape is an abstract metaphor frequently used to represent the
relationship between gene activity and cell fates during development. Over the past few …

Human embryogenesis is hallmarked by two phases of yolk sac development. The primate
hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a …

The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic
tissues, including the placenta. It consists of a spherical thin-walled layer, known as the …

Classic embryological experiments have established that the early mouse embryo develops
via sequential lineage bifurcations. The first segregated lineage is the trophectoderm …

Here we delineate the ontogeny of the mammalian endoderm by generating 112,217 single-
cell transcriptomes, which represent all endoderm populations within the mouse embryo …

The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …

Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we
determine transcriptome dynamics of mouse development from the eight-cell stage to …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Transformation of pluripotent epiblast cells into a cup-shaped epithelium as the mouse
blastocyst implants is a poorly understood and yet key developmental step. Studies of …

The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo
remains controversial. We present transcriptional and functional data to identify the …