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Voltage-gated sodium channels and metastatic disease
Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a
pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in …
pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in …
Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease
Voltage-gated Na+ channel (VGSC) β Subunits are not “auxiliary.” These multi-functional
molecules not only modulate Na+ current (INa), but also function as cell adhesion molecules …
molecules not only modulate Na+ current (INa), but also function as cell adhesion molecules …
Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor
PC May, RA Dean, SL Lowe, F Martenyi… - Journal of …, 2011 - jneurosci.org
According to the amyloid cascade hypothesis, cerebral deposition of amyloid-β peptide (Aβ)
is critical for Alzheimer's disease (AD) pathogenesis. Aβ generation is initiated when β …
is critical for Alzheimer's disease (AD) pathogenesis. Aβ generation is initiated when β …
Therapeutic potential for phenytoin: targeting Nav1.5 sodium channels to reduce migration and invasion in metastatic breast cancer
Abstract Voltage-gated Na+ channels (VGSCs) are heteromeric membrane protein
complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits …
complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits …
A functional null mutation of SCN1B in a patient with Dravet syndrome
Dravet syndrome (also called severe myoclonic epilepsy of infancy) is one of the most
severe forms of childhood epilepsy. Most patients have heterozygous mutations in SCN1A …
severe forms of childhood epilepsy. Most patients have heterozygous mutations in SCN1A …
Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model
Understanding mechanisms that orchestrate cell behavior into appropriately patterned
tissues and organs within the organism is an essential element of preventing, detecting and …
tissues and organs within the organism is an essential element of preventing, detecting and …
Dravet syndrome as part of the clinical and genetic spectrum of sodium channel epilepsies and encephalopathies
Dravet syndrome is the most studied form of genetic epilepsy. It has now been clarified that
the clinical spectrum of the syndrome does not have firmly established boundaries. The core …
the clinical spectrum of the syndrome does not have firmly established boundaries. The core …
Voltage gated sodium channels as therapeutic targets for chronic pain
Being maladaptive and frequently unresponsive to pharmacotherapy, chronic pain presents
a major unmet clinical need. While an intact central nervous system is required for conscious …
a major unmet clinical need. While an intact central nervous system is required for conscious …
[کتاب][B] The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels
JD Calhoun, LL Isom - 2014 - Springer
Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins
that co-purify with pore-forming α subunits in brain. The other family members, β1B, β3, and …
that co-purify with pore-forming α subunits in brain. The other family members, β1B, β3, and …
Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies
Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed
in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi …
in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi …