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A new era for understanding amyloid structures and disease
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
The activities of amyloids from a structural perspective
The aggregation of proteins into structures known as amyloids is observed in many
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …
Structure and aggregation mechanisms in amyloids
The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …
Targeting protein aggregation for the treatment of degenerative diseases
YS Eisele, C Monteiro, C Fearns… - Nature reviews Drug …, 2015 - nature.com
The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …
diseases, which are collectively known as amyloid disorders. However, the mechanistic …
Protein− nanoparticle interactions: opportunities and challenges
In recent years, the fabrication of nanomaterials and exploration of their properties have
attracted the attention of all branches of science, such as physics, chemistry, biology, and …
attracted the attention of all branches of science, such as physics, chemistry, biology, and …
Theory and practice of size exclusion chromatography for the analysis of protein aggregates
Size exclusion chromatography (SEC) is a historical technique widely employed for the
detailed characterization of therapeutic proteins and can be considered as a reference and …
detailed characterization of therapeutic proteins and can be considered as a reference and …
Molecular mechanisms of amyloidosis
G Merlini, V Bellotti - New England Journal of Medicine, 2003 - Mass Medical Soc
Amyloidosis affects millions of people, as a cause of Alzheimer's disease or a complication
of dialysis, and also causes rare conditions. The many forms of the disorder have one …
of dialysis, and also causes rare conditions. The many forms of the disorder have one …
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
We have developed a statistical mechanics algorithm, TANGO, to predict protein
aggregation. TANGO is based on the physico-chemical principles of β-sheet formation …
aggregation. TANGO is based on the physico-chemical principles of β-sheet formation …
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
M Stefani, CM Dobson - Journal of molecular medicine, 2003 - Springer
The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic
feature of more than 20 degenerative conditions affecting either the central nervous system …
feature of more than 20 degenerative conditions affecting either the central nervous system …