Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

General control non-repressible 5 (GCN5)-related N-acetyltransferases (GNAT) catalyze the
transfer of an acyl moiety from acyl coenzyme A (acyl-CoA) to a diverse group of substrates …

Mature red blood cells (RBCs) lack internal organelles and canonical defense mechanisms,
making them both a fascinating host cell, in general, and an intriguing choice for the deadly …

Obligate intracellular parasites must efficiently invade host cells in order to mature and be
transmitted. For the malaria parasite Plasmodium falciparum, invasion of host red blood cells …

N-myristoylation (MYR) is a crucial fatty acylation catalyzed by N-myristoyltransferases
(NMTs) that is likely to have appeared over 2 billion years ago. Proteome-wide approaches …

Malaria-causing parasites of the Plasmodium genus undergo multiple developmental
phases in the human and the mosquito hosts, regulated by various post-translational …

While the global market for peptide/protein-based therapeutics is witnessing significant
growth, the development of peptide drugs remains challenging due to their low oral …

INTRODUCTION Despite the positive effects of intervention strategies that include
insecticide-impregnated bed nets and artemisinin-based drug therapies, malaria still kills …

Genetic manipulation remains a major obstacle for understanding the functional genomics of
the deadliest malaria parasite Plasmodium falciparum. Although the CRISPR/Cas9 …

The malaria parasite Plasmodium spp. varies the expression profile of its genes depending
on the host it resides in and its developmental stage. Virtually all messenger RNA (mRNA) is …