The RAS oncogene is both the most frequently mutated oncogene in human cancer and the
first confirmed human oncogene to be discovered in 1982. After decades of research, in …

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …

From the pioneering work with acute transforming retroviruses to the current post-genomic
era, RAS genes have always been at the leading edge of signal transduction and molecular …

Using in vitro gene amplification by the polymerase chain reaction (PCR) and mutation
detection by the RNAase A mismatch cleavage method, we have examined cK-ras genes in …

The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger
family of at least 35 related human proteins. Using a somewhat broader definition of …

Amplified cellular genes in mammalian cells frequently manifest themselves as double
minute chromosomes (DMs) and homogeneously staining regions of chromosomes (HSRs) …

Molecular cloning of the transforming gene from a chemically transformed human
osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 (7p11. 4 …

The apparent complexity of the genetic, biochemical, and physiological changes in cancer
cells threatens to stall the elucidation of the origins of cancer and the development of new …

Examination of homologies between retroviral oncogenes and transforming sequences
defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is …

Ras proteins play a crucial role as a central component of the cellular networks controlling a
variety of signaling pathways that regulate growth, proliferation, survival, differentiation …