In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …

Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

Exercise exerts a wide range of beneficial effects for healthy physiology 1. However, the
mechanisms regulating an individual's motivation to engage in physical activity remain …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …

Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

The neocortex is disproportionately expanded in human compared with mouse,, both in its
total volume relative to subcortical structures and in the proportion occupied by …

The amygdala is a brain region primarily associated with emotional response. The use of
genetic markers and single-cell transcriptomics can provide insights into behavior …

Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …

Here we present a compendium of single-cell transcriptomic data from the model organism
Mus musculus that comprises more than 100,000 cells from 20 organs and tissues. These …

We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …